Search results for "gold nanostar"

showing 4 items of 4 documents

Gold nanostar–polymer hybrids for siRNA delivery: Polymer design towards colloidal stability and in vitro studies on breast cancer cells

2017

To overcome the low bioavailability of siRNA (small interfering RNA) and to improve their transfection efficiency, the use of non-viral delivery carriers is today a feasible approach to transform the discovery of these incredibly potent and versatile drugs into clinical practice. Polymer-modified gold nanoconstructs (AuNCs) are currently viewed as efficient and safe intracellular delivery carriers for siRNA, as they have the possibility to conjugate the ability to stably entrap and deliver siRNAs inside cells with the advantages of gold nanoparticles, which can act as theranostic agents and radiotherapy enhancers through laser-induced hyperthermia. In this study, AuNCs were prepared by coat…

3003siRNA deliverySmall interfering RNAPolymersMetal NanoparticlesPharmaceutical ScienceGold Colloid02 engineering and technologyPolyethylene Glycol01 natural sciencesPolyethylene GlycolsGold Colloidchemistry.chemical_compoundDrug Delivery SystemsMCF-7 CellDrug StabilityCoatingRNA Small InterferingPolymerDrug Carrierchemistry.chemical_classificationDrug CarriersTumorLipoic acidGold nanostarPolymer021001 nanoscience & nanotechnologyColloidal goldMCF-7 Cells0210 nano-technologyDrug carrierHydrophobic and Hydrophilic InteractionsBreast NeoplasmHumanBiological AvailabilityReproducibility of ResultBreast NeoplasmsNanotechnologyPolyethylene glycolengineering.materialSmall InterferingTransfection010402 general chemistryCell LineHydrophobic and Hydrophilic InteractionMetal NanoparticleCell Line TumorAmphiphileHumansGene SilencingParticle SizeGold nanostarsReproducibility of ResultsGold nanostars; Lipoic acid; MCF-7; PEG; PHEA; siRNA delivery; Biological Availability; Breast Neoplasms; Cell Line; Tumor; Drug Carriers; Drug Delivery Systems; Drug Stability; Gene Silencing; Gold; Gold Colloid; Humans; Hydrophobic and Hydrophilic Interactions; MCF-7 Cells; Metal Nanoparticles; Particle Size; Polyethylene Glycols; Polymers; RNA; Small Interfering; Reproducibility of Results; Transfection; 3003PHEAPEG0104 chemical scienceschemistrySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoengineeringRNAGoldMCF-7Drug Delivery SystemInternational Journal of Pharmaceutics
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New amphiphilic copolymers based on a poly(hydroxyethylaspartamide): coating of Au nanostars to obtain antimicrobial photothermal/delivering systems …

2012

PHEA gold nanostars antimicrobial system photothermal/delivering systems NIR irradiationSettore CHIM/09 - Farmaceutico Tecnologico Applicativo
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Gold nanostars coated with neutral and charged polyethylene glycols: A comparative study of in-vitro biocompatibility and of their interaction with S…

2015

Gold nanostars (GNS) have been coated with four different polyethylene glycols (PEGs) equipped with a -SH function for grafting on the gold surface. These PEGs have different chain lengths with average MW = 2000, 3000, 5000 and average number of -O-CH2-CH2 - units 44, 66, and 111, respectively. Two are neutral and two are terminated with -COOH and -NH2 functions, thus bearing negative and positive charges at physiological pH, thanks to the formation of carboxylate and ammonium groups. The negative charge of the GNS coated with PEG carboxylate has also been exploited to further coat the GNS with the PAH (polyallylamine hydrochloride) cationic polymer. Vitality tests have been carried out on …

Polyethylene glycolBiocompatibilityCell SurvivalMetal NanoparticlesPolyethylene glycolCell morphologyBiochemistryPolyethylene GlycolsInorganic Chemistrychemistry.chemical_compoundNeuroblastomaMicroscopy Electron TransmissionCell Line TumorPEG ratioOrganic chemistryHumansCarboxylatechemistry.chemical_classificationGold nanostarsMolecular StructureEndocytosiCationic polymerizationGold nanostarPolymerEndocytosisTwo-photon luminescenceNanomedicinechemistrySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoBiocompatibilityGoldPolyallylamine hydrochlorideNuclear chemistry
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Amphiphilic Copolymers Based on Poly[(hydroxyethyl)-d,l-aspartamide]: A Suitable Functional Coating for Biocompatible Gold Nanostars

2013

Novel amphiphilic copolymers have been synthesized based on a biocompatible poly(hydroxyethylaspartamide) (PHEA) backbone, bearing both anchoring groups for gold nanoparticles, such as thiols and disulfide, and conjugable moieties, such as amino groups, the latter as points suitable for appending further functional agents. The strategy was to functionalize α,β-poly[(N-2- hydroxyethyl)-d,l-aspartamide] (PHEA) with PEG2000-NH2 and with ethylenediamine (EDA) obtaining a partially pegylated copolymer with a large number of pendant primary amino groups. A fraction of the latter was conjugated with molecules bearing terminal thiol moieties such as 12-mercaptododecanoic acid (MDA) and disulfide gr…

Polymers and PlasticsCell SurvivalMetal NanoparticlesBioengineeringEthylenediamineengineering.materialConjugated systemPolyethylene GlycolsBiomaterialsSurface-Active Agentschemistry.chemical_compoundCoated Materials BiocompatibleCoatingCell Line TumorMaterials TestingAmphiphilePolymer chemistryMaterials ChemistryCopolymerHumansMoleculePoly(hydroxyethyl)-DL-aspartamideParticle Sizechemistry.chemical_classificationAmphiphilic copolymersgold nanostarlipoic acidEthylenediamineschemistrySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoColloidal goldThiolengineeringGoldPeptidesgold nanoparticleBiomacromolecules
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